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An Analysis Of J.B. Christophersons Dosing Method

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Chapter Summary

Christopherson was moving into a relatively unknown and risky course of medication. He went directly to the treatment of his patients. He was rightly cautious in adapting the dosage to the response of the patient. Each 'treatment' was an experimental trial aimed at finding a patient's maximum dose acceptance by a progressive increase while monitoring the response. He then continued the maximum tolerable dose until the parasite was sterile or dead: i.e. there were no further excretions of the ova of the parasite. When we examine his available records with a more modern eye we find that, even if a patients' weight is unknown, age, as a surrogate measure, would have permitted a reasonably accurate calculation of the necessary dose.

Keywords: dosing method; J.B. Christopherson



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