Cookies Policy
X

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

GAP-43 immunoreactivity is enhanced after UV irradiation in the peripheral nervous system of the rat

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Primary Sensory Neuron
For more content, see Sensory Neuron.

UV irradiation evoked thermal and mechanical hypersensitivity in the glabrous skin of the rat hind paw. During the period of hyperalgesia skin samples were taken from irradiated areas of the skin and the corresponding segments of the spinal cord, and the expression of growth-associated protein 43 (GAP-43) was quantitatively measured. Although GAP-43 was present in a small number of fibers in the skin of control animals, the total length of GAP-43 positive fibers per unit area was significantly increased within 3 days after irradiation in both ipsi- and contralateral hind limbs. The time course of GAP-43 expression corresponded to that of mechanical hyperalgesia. GAP-43 immunopositivity was at its maximum on day 3 after UV irradiation and declined to control level at day 14. Increased GAP-43 immunoreactivity was similar in both hind paws except on day 3 when it was significantly more on the ipsilateral side. Most GAP-43-positive fibers were arborizing branches in the skin, but strong positivity was found around blood vessels and around sweat glands. Glyoxylic acid-induced fluorescent-catecholamine marking was associated with blood vessels without extravascular sprouting in control or UV-irradiated skin. At 3 and 5 days after UV irradiation GAP-43-positive profiles were present in the spinal L4-5 segments. GAP-43 immunoreactivity was detected on both sides in the dorsal horn with greater intensity on the ipsilateral side. We conclude that the increased expression of GAP-43 in neuronal processes of the ipsi- and contralateral paw after UV irradiation is most unlikely to be directly associated with nerve sprouting. GAP-43 expression occurred mainly in sensory fibers.

10.1163/092996397750131874
/content/journals/10.1163/092996397750131874
dcterms_title,pub_keyword,dcterms_description,pub_author
6
3
Loading
Loading

Full text loading...

/content/journals/10.1163/092996397750131874
Loading

Data & Media loading...

http://brill.metastore.ingenta.com/content/journals/10.1163/092996397750131874
Loading

Article metrics loading...

/content/journals/10.1163/092996397750131874
1997-03-01
2016-12-05

Sign-in

Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
     
    Primary Sensory Neuron — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation