Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Lack of specificity in the interactions of cranial sensory and motoneuron axons in vitro

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Primary Sensory Neuron
For more content, see Sensory Neuron.

During embryogenesis sensory innervation is established quite precisely, but the mechanisms responsible are poorly understood. Whereas sensory neurons that supply muscle appear to require nearby motor axons to reach their target muscles, sensory neurons that supply skin do not. We have investigated the specificity with which sensory axons interact with motor axons, using the avian trigeminal sensory system, where prospective cutaneous and muscle afferents are anatomically separate. To test whether muscle afferents selectively associate with the appropriate motor axons, we co-cultured muscle afferents from the trigeminal mesencephalic nucleus with appropriate trigeminal motoneurons from rhombomeres 2/3 and with inappropriate facial motoneurons from rhombomeres 4/5. To test whether prospective cutaneous and muscle afferents can be distinguished by their interactions with motor axons, we cocultured cutaneous neurons from trigeminal ganglia with trigeminal motoneurons. Dye labeling and time-lapse videomicroscopy revealed no obvious differences between the interactions of muscle afferents with appropriate and inappropriate motor axons or between the interactions of cutaneous and muscle afferents with motor axons. Sensory axons intermixed freely with and crossed over motor axons without fasciculating, regardless of the combination of sensory and motor axons examined. These results suggest that outgrowing sensory neurons may not yet have distinct identities, raising the possibility that sensory innervation patterns are determined more by spatial or temporal constraints on axon growth than by active pathway or target selection. In contrast, motor axons often retracted upon contacting sensory afferents, indicating that there are marked differences between sensory and motor growth cones at the stages studied.

Affiliations: 1: Department of Neurobiology and Anatomy , University of Utah School of Medicine, 50 N. Medical Drive, Salt Lake City, UT 84132, USA


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Primary Sensory Neuron — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation