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Geographic variations of melanocortine 1 receptor gene (MC1R) in the common frog (Rana temporaria) in Northern Europe

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The melanocortin 1 receptor (MC1R, or MSH receptor) of melanophores (pigment-containing cells) receives pigmentation signals from the pituitary, and is likely to play a crucial role in the background color adaptation and the dorsal pigment patterning in amphibians. As such, these genes are likely to be under strong selection at particular habitats and at the same time exhibit geographic variations by neutral substitution at other habitat within species. To investigate geographic clines in the MC1R gene variability in the common frog (Rana temporaria), the coding region sequence was analyzed across Northern European populations. Interestingly, the two colonization routes in Fennoscandia (Eastern and Western) showed different evolutionary stories regarding the MC1R gene. Higher variation in both nucleotide and predicted amino acid sequences were found on the Eastern as compared to the Western side of Fennoscandia. The variation in Western Fennonscandia was very low and nearly mono-allelic. This result is consistent with a recent and rapid recolonization from the South (Denmark), and/or strong selection on one favorable allele in the western side of Fennoscandia.

1. Aljanabi S.M. , Martinez I. ( 1997): "Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques". Nuc. Acid Res. Vol 25: 4692- 4693. http://dx.doi.org/10.1093/nar/25.22.4692
2. Bagnara J.T. ( 1998): "Comparative anatomy and physiology of pigment cells in nonmammalian tissues". In: The pigmentary system, p.  9- 40. Nordlund J.J. , Boissy R.E. , Hearing V.J. , King R.A. , Ortonne J.-P. , Eds, Oxford University Press, New York.
3. Bittner T.D. , King R.B. , Kerfin J.M. ( 2002): "Effects of body size and melanism on the thermal biology of garter snakes ( Thamnophis sirtalis)". Copeia Vol 2002: 477- 482. http://dx.doi.org/10.1643/0045-8511(2002)002[0477:EOBSAM]2.0.CO;2
4. Clement M. , Posada D. , Crandall K.A. ( 2000): "TCS: a computer program to estimate gene genealogies". Mol. Ecol. Vol 9: 1657- 1659. http://dx.doi.org/10.1046/j.1365-294x.2000.01020.x
5. Eizrik E. , Yuhki N. , Johnson W.E. , Menotti-Raymond M. , Hannah S.S. , O’Brien S. ( 2003): "Molecular genetics and evolution of melanism in the cat family". Curr. Biol. Vol 13: 448- 453. http://dx.doi.org/10.1016/S0960-9822(03)00128-3
6. Fu Y.-X. , Li W.-H. ( 1993): "Statistical tests of neutrality of mutations". Genetics Vol 133: 693- 709.
7. Heatwoles H. ( 1994): Amphibian biology. Surrey and Beatty & Sons, Chipping Norton, NSW.
8. Herczeg G. , Matsuba C. , Merilä J. ( 2010): "Sequence variation in the melanocortin-1 receptor gene (Mc1r) does not explain variation in the degree of melanism in a widespread amphibian". Ann. Zool. Fennici Vol 47: 37- 45. http://dx.doi.org/10.5735/086.047.0104
9. Hewitt G.M. ( 1999): "Post-glacial re-colonization of European biota". Biol. J. Linn. Soc. Vol 68: 87- 112. http://dx.doi.org/10.1111/j.1095-8312.1999.tb01160.x
10. Hewitt G.M. ( 2001): "Speciation, hybrid zone and phylogeography – or seeing genes in space and time". Mol. Ecol. Vol 10: 537- 549. http://dx.doi.org/10.1046/j.1365-294x.2001.01202.x
11. Hoffman E.A. , Blouin M.S. ( 2000): "A review of colour and pattern polymorphisms in anurans". Biol. J. Linn. Soc. Vol 70: 633- 665. http://dx.doi.org/10.1111/j.1095-8312.2000.tb00221.x
12. Jaarola M. , Tegelström H. ( 1995): "Colonization history of north European field voles ( Microtus agrestis) revealed by mitochondrial DNA". Mol. Ecol. Vol 4: 299- 310. http://dx.doi.org/10.1111/j.1365-294X.1995.tb00223.x
13. Klovins J. , Haitina T. , Fridmanis D. , Kilianova Z. , Kapa I. , Fredriksson R. , Gallo-Payet N. , Schioth H.B. ( 2004): "The melanocortin system in fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs". Mol. Biol. Evol. Vol 21: 563- 579. http://dx.doi.org/10.1093/molbev/msh050
14. Knopp T. , Merilä J. ( 2009): "The postglacial recolonization of Northern Europe by Rana arvalisas revealed by microsatellite and mitochondrial DNA analyses". Heredity Vol 102: 174- 181. http://dx.doi.org/10.1038/hdy.2008.91
15. Kumar S. , Tamura K. , Nei M. ( 2004): "MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment". Brief Bioinfo. Vol 5: 150- 163. http://dx.doi.org/10.1093/bib/5.2.150
16. Makova K. , Norton H. ( 2005): "Worldwide polymorphism at the MC1R locus and normal pigmentation variation in humans". Peptides Vol 26: 1901- 1908. http://dx.doi.org/10.1016/j.peptides.2004.12.032
17. Matsuba C. , Miura I. , Merila J. ( 2008): "Disentangling genetic vs. environmental caused of sex determination in the common frog, Rana temporaria ". BMC Genetics Vol 9: 3. http://dx.doi.org/10.1186/1471-2156-9-3
18. Maynard Smith J.M. ( 1992): "Analyzing the mosaic structure of genes". J. Mol. Evol. Vol 34: 126- 129.
19. Mundy N.I. ( 2005): "A window on the genetics of evolution: colouration in birds and plumage MC1R ". Proc. R. Soc. B Vol 272: 1633- 1640. http://dx.doi.org/10.1098/rspb.2005.3107
20. Nachman M.W. , Hoekstra H.E. , D’Agostino S.L. ( 2003): "The genetic basis of adaptive melanism in pocket mice". Proc. Natl. Acad. Sci. U.S.A. Vol 100: 5268- 5273. http://dx.doi.org/10.1073/pnas.0431157100
21. Nadeau N.J. , Minvielle F. , Mundy N.I. ( 2006): "Association of a Glu92Lys substitution in MC1Rwith extended brown in Japanese quail ( Coturnix japonica)". Anim. Gen. Vol 37: 287- 289. http://dx.doi.org/10.1111/j.1365-2052.2006.01442.x
22. Nei M. , Gojobori T. ( 1986): "Simple methods for estimating the numbers of synonymous and nonsynonymous substitution rates among sites". Mol. Biol. Evol. Vol 13: 650- 659.
23. Nei M. , Tajima F. , Tateno Y. ( 1983): "Accuracy of estimated phylogenetic trees from molecular data". J. Mol. Evol. Vol 19: 153- 170. http://dx.doi.org/10.1007/BF02300753
24. Niskanen M. , Mappes J. ( 2005): "Significance of the dorsal zigzag pattern of Vipera latastei gaditanaagainst avian predators". J. Anim. Ecol. Vol 74: 1091- 1101. http://dx.doi.org/10.1111/j.1365-2656.2005.01008.x
25. Nunes V.L. , Marildo A. , Beaumont M.A. , Butlin R.K. , Paulo O.S. ( 2011): "Association of Mc1rvariants with ecologically relevant phenotypes in the European ocellated lizard, Lacerta lepida ". J. Evol. Biol. Vol 24: 2289- 2298. http://dx.doi.org/10.1111/j.1420-9101.2011.02359.x
26. Palo J.U. , Schmeller D.S. , Laurila A. , Primmer C.R. , Kuzmin S.L. , Merilä J. ( 2004): "High degree of population subdivision in a widespread amphibian". Mol. Ecol. Vol 13: 2631- 2644. http://dx.doi.org/10.1111/j.1365-294X.2004.02269.x
27. Peganeau G. , Gardner M. , Eyer-Walker A. ( 2004): "A broad survey of recompination in animal mitochondoria". Mol. Biol. Evol. Vol 21: 2319- 2325. http://dx.doi.org/10.1093/molbev/msh244
28. Posada D. , Crandall K.A. ( 2001): "Intraspecific phylogenetics: Trees grafting into networks". Trends in Ecology and Evolution Vol 16( 1): 37- 45. http://dx.doi.org/10.1016/S0169-5347(00)02026-7
29. Richards C.M. , Nace G.W. ( 1983): "Dark pigment variations in Anurans: classification, new descriptions, color changes and inheritance". Copeia Vol 1983: 979- 990. http://dx.doi.org/10.2307/1445100
30. Rosenblum E.B. , Hoekstra H.E. , Nachman M.W. ( 2004): "Adaptive reptile color variation and the evolution of the MC1R gene". Evolution Vol 58: 1794- 1808.
31. Rozas J. , Rozas R. ( 1999): "DnaSP version 3: an integrated program for molecular populations genetics and molecular evolution analysis". Bioinformatics Vol 15: 174- 175. http://dx.doi.org/10.1093/bioinformatics/15.2.174
32. Schmitt T. ( 2007): "Molecular biogeography of Europe: Pleistocene cycles and postglacial trends". Frontiers in Zoology Vol 4: 11. http://dx.doi.org/10.1186/1742-9994-4-11
33. Stephens M. , Smith N.J. , Donnelly P. ( 2001): "A new statistical method for haplotype reconstruction from population data". Human Genet. Vol 68: 978- 989. http://dx.doi.org/10.1086/319501
34. Taberlet P. , Bouvet J. ( 1994): "Mitochondrial DNA polymorphism, phylogeography, and conservation genetics of the brown bear ( Ursus arctos) in Europe". Proc. R. Soc. Lond. B Vol 255: 195- 200. http://dx.doi.org/10.1098/rspb.1994.0028
35. Taberlet P. , Fumagalli L. , Hausser J. ( 1994): "Chromosomal versus mitochondrial DNA evolution: tracking the evolutionary history of the southwestern European population of the Sorex araneusgroup (Mammalia, Insectivora)". Evolution Vol 48: 623- 636. http://dx.doi.org/10.2307/2410474
36. Tajima F. ( 1989): "Statistical method for testing the neutral mutation hypothesis by DNA polymorphism". Genetics Vol 123: 585- 595.
37. Tanosaki Y. , Cruijsen P.N. , Nishiyama K. , Yaginuma H. , Roubos E.W. ( 2004): "Low temperature stimulates alpha-melanophore-stimulating hormone secretion and inhibits background adaptation in Xenopus laevis ". J. Neuroendocrinol. Vol 16( 11): 894- 905. http://dx.doi.org/10.1111/j.1365-2826.2004.01247.x
38. Theron E. , Hawkins K. , Bermingham E. , Richlefs R.E. , Mundy N. ( 2001): "The molocular basis of an avian plumage polymorphism in the wild: a melanocortin-1-receptor mutation is perfectly associated with the melanic plumage morph of the bananaquit ( Coerebra flaveola)". Curr. Biol. Vol 11: 550- 557. http://dx.doi.org/10.1016/S0960-9822(01)00158-0
39. Vences M. , Gala’n P. , Vieites D.R. , Puente M. , Oetter K. , Wanke S. ( 2002): "Field body temperatures and heating rates in a montane frog population: the importance of black dorsal pattern for thermoregulation". Ann. Zool. Fennici Vol 39: 209- 220.
40. Wuster W. , Allum C.S.E. , Bjargardóttir I.B. , Bailey K.L. , Dawson K.J. , Guenioui J. , Lews J. , McGurk J. , Moore A.G. , Niskanen M. , Pollard C.P. ( 2004): "Do aposematism and batesian mimicry require bright colours? A test using European viper markings". Proc. R. Soc. Lond. B Vol 271: 2495- 2499. http://dx.doi.org/10.1098/rspb.2004.2894
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/content/journals/10.1163/156853812x624441
2012-01-01
2015-08-28

Affiliations: 1: Ecological Genetics Research Unit, Department of Biological and Environmental Sciences, University of Helsinki, PO Box 65, FI-00014 Finland Present address: Department of Biology, University of Florida, 223 Bartram Hall, PO Box 118525, Gainesville, FL 32611-8525, USA E-mail: matsuba@ufl.edu

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