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The Production of Stocks of Albino Mice With

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Through selective breeding, four strains or albino mice with predictable susceptibilities to audiogenic seizures have been produced from originally random stock. Two of these have high (90-100 %) susceptibility to seizures when tested daily from 15-50 days of age. Mice of one of these strains are highly susceptible to clonic-tonic seizures, but rarely die in this type of seizure, as highly susceptible mice usually do. Those of the second strain have high susceptibility to clonic seizures, but have few clonic-tonic seizures. Mice of the third strain have a very low (0-10%) susceptibility to seizures during the testing period, with up to 70 % of the mice having no seizures at all. Individuals of the fourth strain have seizures regularly from 17-27 days of age, but not afterward. These strains are useful for genetic and physiological studies on audiogenic seizures in mice, since the mice in each have predictable and uniform records.

Affiliations: 1: (Pennsylvania State College, State College, Pa., U.S.A.


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