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Action De Deux Inhibiteurs D'Enzymes Intervenant Dans Le Metabolisme Des Pterines Chez Artemia Salina (L.) (Phyllopoda) En Milieu Axenique

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image of Crustaceana

The use of two antagonists inhibiting respectively folic acid reductase and xanthine oxidase, shows a possible link between the pterin-pteridine metabolism, morphogenesis differenciation and melanogenesis. Folic acid is necessary for thymidine synthesis during larval growth. Apart from growth inhibition, pathological features concerning morphogenesis and pigmentation have been observed on larvae reared in the presence of aminopterin. The antagonist causes a melanogenetic reaction (black disease) from the juvenile stage on, preventing the animals to reach sexual maturity. Folic acid is necessary for sexual maturity but is melanogenetic when added to juveniles reared in the absence of the vitamin. The inhibition of xanthine oxidase causes the same black disease in addition to riboflavine deficiency a co-factor of xanthine oxidase as flavine adenine dinucleotide. A slight inhibition of the enzyme seems to speed up male sexual différenciation. These results are discussed in terms of changes in enzymatic activities corresponding to developmental stages.

Affiliations: 1: Laboratoire de Physiologie Générale du Muséum National d'Histoire Naturelle, Paris, France


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