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Neurodepressing Hormone (Ndh): Fact or Fiction?

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image of Crustaceana

Extracts of the crustacean eyestalk, and particularly of the sinus gland, produce an inhibition of the spontaneous firing rate of motor and sensitive neurons in two different bioassays. This activity can be ascribed to a molecule of low molecular weight, neutral, non-peptidic, soluble in water and methanol, thermostable, different from GABA but suppressed by picrotoxin. Its nature remains to be elucidated.

Affiliations: 1: Instituto Nacional dc la Nutrición "Salvador Zubirán", Department of Biochemistry, Vasco de Quiroga 15, Tlalpan, 14000 Mexico, D.F., Mexico


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