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Saffan®: a Review and Some Examples of Its Use in Fishes (Pisces: Teleostei)

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image of Netherlands Journal of Zoology
For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

Saffan®, previously known as CT1341, is an injectable steroid anesthetic for use in cats and monkeys. It is also suited to induce anesthesia in fishes. It has the convenient property to induce anesthesia of the central nervous system, and to leave the sensory system of the integument operational. The active constituents are alphaxalone and alphadolone. A dose of 24 mg/kg i.m. is sufficient for 2 to 3 hours narcosis in fish of several hundreds of grams. For small specimens administration via bath-water in doses of 2 to 4.8 mg/l for induction and half this dose for maintenance are advisable. In catfish, Ictalurus nebulosus and I. melas, of 100 g or more the induction time after i.m. injection with 21 mg/kg is about 20 min and independent of weight or temperature. The recovery time varies with temperature from 213 min at 13°C to 19 min at 19°C. In 1000 g catfish, Clarias gariepinus, the onset of surgical anesthesia occurs after 26 min on average at doses of 24 mg/kg at 24°C. In 5 g catfish, Kryptopterus bicirrhis, 4.8 mg/l bath water at 25°C makes the opercular movements disappear after 5 min. For 15 cm TL Gnathonemus petersii a good induction dose is 2 mg/l bathwater. After 20 minutes at 23°C surgical narcosis is reached.

Affiliations: 1: Utrecht University, Comparative Physiology, Padualaan 8, 3584 CH Utrecht-NL


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