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Direct Mass Spectrometry of Buccal Ganglia and Nerves Reveals the Processing and Targeting of Peptide Messengers Involved in Feeding Behaviour of Lymnaea

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image of Netherlands Journal of Zoology
For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

Feeding in molluscs is initiated and modulated by central neurons, especially those located in the buccal ganglia. Many of these neurons use diverse peptides as neuro-messengers. Direct matrix-assisted laser desorption mass spectrometric analysis of tissues demonstrates that a large number of peptides are present in the buccal ganglia. Furthermore, the newly identified -LFRFamide peptides are shown to target to both the buccal mass and the oesophagus, whereas Lymnaea inhibitory peptide is shown to target to the oesophagus. In accordance to the mass spectrometric data, immunocytochemistry using antibodies against Lymnaea inhibitory peptide indicates that the nerves that innervate the oesophagus are indeed heavily immunoreactive, and the nerves that innervate the buccal mass are only faintly immunoreactive.

Affiliations: 1: Graduate School Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, Faculty of Biology, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands; 2: TNO-IBC, Center for Structure Elucidation and Instrumental Analysis, P.O. Box 360, 3700 AJ Zeist, The Netherlands


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