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Molecular Cloning and Neuronal Expression of a Novel Type of a G-Protein-Coupled Receptor With Ldl Binding Motifs From the Pond Snail Lymnaea Stagnalis

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For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

We have isolated and characterized a cDNA encoding a novel type of receptor from the central nervous system (CNS) of the pond snail Lymnaea stagnalis. This receptor appears to be a natural hybrid between two classes of receptor proteins. The N-terminal part of the protein contains two types of repeated sequences; the first displays a high degree of sequence similarity with the extracellular binding domains of the low density lipoprotcin (LDL) receptor, which binds, internalizes, and releases cholesterol containing apolipoproteins. The second type of repeat, and the C-tcrminal part of this receptor arc homologous to specific regions of a class of G-protein-coupled receptors, the mammalian glycoprotein hormone receptor family. The mRNA encoding the receptor is predominantly located in the CNS in a small cluster of 90 neurons within the pedal ganglia, and to a lesser extent in the heart. The discovery of this chimeric receptor and its neuronal expression indicates the presence of a new subclass of G-protein-coupled receptors that may be involved in the transduction of signals carried by lipoproteins into neuronal events via G-proteins.

Affiliations: 1: Gradutate School of Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, Faculty of Biology, Department of Zoology, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands; 2: Gradutate School of Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, Faculty of Chemistry, Department of Biochemistry and Molecular Biology, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands; 3: Gradutate School of Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit; 4: Faculty of Biology, Department of Zoology, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands; 5: Sussex Neuroscience Research Centre, School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom

10.1163/156854293X00548
/content/journals/10.1163/156854293x00548
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/content/journals/10.1163/156854293x00548
1993-01-01
2017-01-21

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