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Hedgehog Signalling in Drosophila and Vertebrate Development

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image of Netherlands Journal of Zoology
For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

The hedfielwg (hh) gene family encode secreted proteins that are involved in a number of developmental processes in vertebrates and invertebrates. These include the patterning of the vertebrate neural tube, somites, limb and brain and the Drosophila embryonic epidermis and larval imaginal discs. Hh proteins show a high degree of sequence identity within and between species. Recent analysis has demonstrated that this family of molecules may act in a mechanistically similar way to provide positional signalling within different phyla.

Affiliations: 1: Mnleccular Embryology Laboratory Imperial Callar Research Fund 44 Linclon's Inns Field, London WC2A 3PX. UK


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