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Endogenous Angiotensins, Angiotensin Ii-Competitive Binding Inhibitors and Converting Enzyme Inhibitor in Elasmobranch Fish

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image of Netherlands Journal of Zoology
For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

This study demonstrates the potent vasopressor activity of homologous dogfish angiotensin (A) I and II. The AII competitive binding inhibitors [Sar1-Val5-Ala8]-AII and [Sar1-IIe8]-AII did not inhibit the pressor action of dogfish AII but the converting enzyme inhibitor captopril effectively blocked conversion of AI to AII.

Affiliations: 1: Gatty Marine Laboratory, University of St Andrews, Scotland, U.K.; 2: National Research Institute of Fisheries Science, Yokohama, Japan; 3: Ocean Research Institute, University of Tokyo, Japan


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