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Effects of Insulin-Like Growth Factor I (Igf-I) On Steroid Production By Isolated Ovarian Theca and Granulosa Layers of Preovulatory Coho Salmon

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image of Netherlands Journal of Zoology
For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

The effects of recombinant human and salmon insulin-like growth factor-I (IGF-I) on in vitro steroid production by isolated theca and granulosa cell-layers of the preovulatory coho salmon ovary were examined. Prior to germinal vesicle breakdown (GVBD), IGF-I decreased basal theca cell-layer production of testosterone (T) and 17α-hydroxy-progesterone (17OH-P) and also inhibited the stimulatory effects of gonadotropin II (GTH II) on T production. After GVBD, IGF-I lowered the GTH II-induced production of both steroids by theca cells. In contrast, IGF-I enhanced the stimulatory effects of GTH II on conversion of 17OH-P to 17α,20β-dihydroxy-4-pregnen-3-one (17,20β-P) by granulosa cells during final oocyte maturation.

Affiliations: 1: Dept. of Biochemistry and Physiology, University of Barcelona, Spain; 2: University of Washington, Seattle, WA; 3: Northwest Fisheries Center, Seattle, WA, USA


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