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Effect of Pacap On Lh Release and Intracellular Calcium Mobilization in Porcine Pituitary Cells

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For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

Pituitary adenylate cyclase-activating polypeptide (PACAP) is suggested to control the activity of pituitary cells. Here we demonstrate that PACAP acts directly on gonadotrope cells increasing LH release, modulating the action of Gonadotropin Releasing Hormone (GnRH) and inducing mobilization of free cytosolic calcium ([Ca2+]i). PACAP could play a physiological role in the regulation of the hypothalamic-pituitary-gonadal axis.

Affiliations: 1: Department of Cell Biology, University of Córdoba, Spain; 2: European Institute for Peptide Research, Lab. Cell. Mol. Neuroencrinol., INSERM U413, UA CNRS, University of Rouen, France


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