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Endocrine Pancreas Morphogenesis of Bufo Bufo During Metamorphosis

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image of Netherlands Journal of Zoology
For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

Anatomical modifications, immunohistochemistry and cytology of the pancreas during metamorphosis of Bufo bufo were studied. Endocrine insulin-producing cells appear at the beginning of metamorphosis, cells producing glucagon, somatostatin (14) and pancreatic polypeptide (PP) appear together, a few days later. Extensive anatomical remodelling, determined by programmed cell death and mitosis occurred during metamorphic climax and later, until the adult structure is attained.

Affiliations: 1: Dipartimento di Biologia Animale e dell'Uomo, Università di Roma 'La Sapienza', Viale dell'Uni-versità 32, 00185 Roma, Italy


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