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The Pituitary Transcription Factor Ghf-1 /Pit-1: an Evolutionary Overview

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For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

Growth hormone (GH) transcription factor 1 (GHF-1) or pituitary transcription factor 1 (Pit-1) is a pituitary gland-specific homeodomain protein of the POU subclass. POU proteins exert critical developmental and transcriptional functions. Two functional regions, the DNA-binding or POU domain and the transcriptional serine-threonine activation domain (STA) are highly conserved between fishes and primates. However, a variability in the length of the STA domain (between 71 and 128 amino acid residues) is found in different species as well as isoforms generated by alternative splicing.

Affiliations: 1: Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain


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