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Amino Acid Sequences of N-Terminal Procalcitonin of Some Vertebrates

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For more content, see Archives Néerlandaises de Zoologie (Vol 1-17) and Animal Biology (Vol 53 and onwards).

In the present study, the complete amino acid sequence of N-terminal procalcitonins (N-proCTs) of stingray (an elasmobranch) and spotlined sardine (a teleost), as well as the partial amino acid sequence of N-proCTs of goldfish (a teleost; three types of N-proCTs) and bullfrog (an amphibian) have been determined. These N-proCTs have some common features to 9 N-proCTs sequenced to date. These features were summarized as follows: 1) The first amino acid residue is Ala or Val. 2) There is no Cys residue in the sequence of N-proCTs. 3) Seven residues (Pro3, Leu19, Leu28, Val32, Gln37, Gln45 and Ser56) are conserved in the sequence of N-terminal procalcitonin (N-proCT), at least judging from the present data. 4) Insertion/deletion points are present in the sequence of N-proCTs at the 2nd position, from the 10th to 14th and from 46th to 52nd. We examined whether the N-proCTs can be categorized into several groups by similarity of amino acid residues conserved in the molecules. As a result, the N-proCTs were roughly categorized into 2 groups: a mammalian group, including 2 subgroups and a non-mammalian group, including 3 subgroups. This classification of N-proCTs coincides with that of calcitonin. Sardine N-proCT has no accelerating effects on mitosis and cell differentiation of human osteosarcoma cells, as does the homologous human N-proCT. Further studies are needed to elucidate the biological activity of N-proCTs.

Affiliations: 1: Noto Marine Laboratory, Faculty of Science, University of Kanazawa, Uchiura, Ishikawa 927-0553, Japan; 2: Sumitomo Metal Industries, Ltd., Chiyoda-Ku, Tokyo 100-0004, Japan; 3: Department of Biology, Faculty of Science, Tomaya University, Gofuku 3190, Toyama 930-0887, Japan; 4: Οcean Research Institute, University of Tokyo, Nakano-Ku, Tokyo 164-0014, Japan; 5: Laboratory of Molecular Endocrinology, School of Fisheries Sciences, University of Kitasato, Sanriku, Iwate 022-0101, Japan; 6: The Kambegawa Laboratory, Komae, Tokyo 201-0013, Japan; 7: Department of Zoology, University of Gorakhpur, Gorakhpur 273009, India

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