Cookies Policy
X

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Evaluation of poly(DL-lactide-co-glycolide) nanoparticles as matrix material for direct compression

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Buy this article

Price:
$30.00+ Tax (if applicable)
Add to Favorites

image of Advanced Powder Technology

The objectives of this study were to prepare matrix tablets with poly(DL-lactide-co-glycolide) (PLGA) particles and drug by direct compression and to evaluate the effects of altering the PLGA particle size, compression pressure, drug species and the PLGA nanoparticle content on compressibility and compactibility. In addition, the release rates of drugs from matrix tablets were evaluated and the release mechanism will be discussed. PLGA nanoparticles were prepared by the modified spontaneous emulsification solvent diffusion method, while PLGA microparticles were prepared by a solvent evaporation method. Tablets were prepared by direct compression. The tablet strength, porosity, release profile, molecular weight and tablet weight were examined. The compressibility of PLGA particles tended to become slightly poorer with decreasing particle size, while the nanoparticles gave significantly better compactibility compared to microparticles. The incorporation of nanoparticles was more effective in retarding drug release than microparticles. The addition of nanoparticles improved the compressibility and compactibility regardless of drug species, and their release rates were dependent on the solubility of drugs. At low nanoparticle content (20%), the drug was completely released within a period of 20 h, while the drug release showed a biphasic release pattern at higher nanoparticle contents. Analysis of the release mechanism indicated that the first phase of drug release corresponded to the diffusion theory, while the second phase seemed to be due to degradation of PLGA. We conclude that PLGA nanoparticles provide significant compactibility and could be useful as a retardant material for matrix tablets by direct compression.

Loading

Article metrics loading...

/content/journals/10.1163/156855200750172187
2000-09-01
2015-07-30

Sign-in

Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to email alerts
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Name:*
    Email:*
    Your details
    Name:*
    Email:*
    Department:*
    Why are you recommending this title?
    Select reason:
     
     
     
     
    Other:
     
    Advanced Powder Technology — Recommend this title to your library

    Thank you

    Your recommendation has been sent to your librarian.

  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation