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Relationship between micromeritical properties and dispensability of fine granules and granules prepared by the extrusion granulation method

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Through the use of fine granules and granules prepared by the extrusion granulation method, we investigated the relationship between micromeritical properties and dispensability, and assessed the particle size distribution and content uniformity (mesh cut assay) of these fine granules and granules. The results showed that the dispensability of fine granules and granules, prepared by the extrusion granulation method, could be assessed according to previously reported standards established for granules prepared by the fluidized bed granulation method. In other words, the dispensability of these fine granules and granules was fine when the PM index was >120, the ML index was >140 and Carr's fluidity index was between 80 and 90. Also, the advantages associated with granules prepared by this method are superior drug content uniformity (even at contents of about 0.1%) and narrow particle size distribution.


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