Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Fluidized bed binderless granulation of hydrophobic drugs with fine lactose powder

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

This Article is currently unavailable for purchase.
Add to Favorites
You must be logged in to use this functionality

To examine the applicability of pressure swing granulation (PSG), a fluidized bed binderless granulation method, to the production of pharmaceutical granules, the effects of drug particle size and concentration on the properties of PSG granules were investigated. The hydrophobic model drug powder and the model excipient powder used in this work were jet-milled 2-ethoxybenzamide (ethenzamide) powder and jet-milled lactose powder, respectively. Spherical granules of 355-1410 μm diameter were obtained with a high yield. The strength of product granules increased with increasing ethenzamide concentration when fine ethenzamide particles (dp,50 = 4.0 μm) were mixed with fine lactose (dp,50 = 3.8 μm). However, when coarse ethenzamide particles (dp,50 = 7.1 μm) were mixed with fine lactose powder (dp,50 = 3.1 μm), the tensile strength remained relatively constant regardless of the drug concentration. The product granules were sufficiently strong to maintain their shape during storage and sufficiently weak to disintegrate under a small compaction force. The drug contents in the product PSG granules were in good agreement with the predetermined values showing the good content uniformity of PSG products.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation