Cookies Policy
X

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Effects of lubricant mixing on compression properties of various kinds of direct compression excipients and physical properties of the tablets

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the Brill platform automatically have access to the MyBook option for the title(s) acquired by the Library. MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Access this article

+ Tax (if applicable)
Add to Favorites

image of Advanced Powder Technology

The effects of lubricant [magnesium stearate MgSt] mixing time on the characteristics of tablet formulation were investigated by using two types of mixers (twin-shell and high-speed mixers). Three kinds of excipients for the direct compression — spray-dried lactose (SDL), microcrystalline cellulose (MCC) and dibasic calcium phosphate anhydrous (DCPA) — were mixed with a lubricant, MgSt, by using a twin-shell or high-speed mixer, respectively. The tablets were compressed from the mixed powders at 98 MPa. The compression parameters of the tablets, such as the tensile strength, compression energy, compression availability and elastic recovery ratio, were evaluated based on the compression profiles and the tablet hardness. The tablet hardness of MCC decreased with an increase in mixing time in the high-speed mixer and the related compression properties of MCC changed depending on the hardness, but those of DCPA did not. The order of the effect of mixing was MCC > SDL > DCPA and the high-speed mixer was more effective than the twin-shell mixer. We conclude that the compression properties of DCPA did not fluctuate by mixing with MgSt under any conditions compared with other excipients.

http://brill.metastore.ingenta.com/content/journals/10.1163/1568552041270563
Loading

Article metrics loading...

/content/journals/10.1163/1568552041270563
2004-07-01
2016-02-10

Sign-in

Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Name:*
    Email:*
    Your details
    Name:*
    Email:*
    Department:*
    Why are you recommending this title?
    Select reason:
     
     
     
     
    Other:
     
    Advanced Powder Technology — Recommend this title to your library

    Thank you

    Your recommendation has been sent to your librarian.

  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation