Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Pharmaceutical powder technology — from art to science: the challenge of the FDA's Process Analytical Technology initiative

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Advanced Powder Technology

This paper describes with typical examples the state of art. The list of examples includes the problems of non-robust formulations and critical processes. The paper demonstrates the necessity and the challenge of the FDA's Process Analytical Technology initiative, which is an important stimulus to develop a rigorous scientific framework in the area of pharmaceutical powder technology. The paper suggests a kind of 'road map' to achieve as fast as possible the top of the 'knowledge pyramid'. The road map includes the extensive use of a multivariate design of experiments, the use of artificial neural networks (ANN), the use of the laws of physical pharmacy and percolation theory, and, last but not least, tries to 'translate' the existing laws of physical chemistry into the area of pharmaceutical powder technology, where we have the problem that the number of particles involved is much lower than the Avogadro number NA. For this reason it will be of interest to monitor closely the progress in nanoscience, especially in the area of mathematical modeling of the fascinating special physical properties of nanoparticles, which again consist of a finite number N of atoms, respectively molecules, with NNA .


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Advanced Powder Technology — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation