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Application of a newly defined capping index in evaluation of the compressibility of pharmaceutical powders

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_The compressibility of pharmaceutical powders was evaluated using the capping index which was newly defined as the ratio of the residual die wall pressure to the binding strength of compacts. As the compaction pressure was increased, the residual die wall pressure increased while the binding strength reached a plateau, and the resultant capping index increased. These facts explained the capping behaviors during tableting under various compaction pressures. In the case of a binary powder mixture, the residual die wall pressure changed in a simple manner with a change in powder composition while the binding strength changed in a complex manner. It was found that the capping tendency of these mixtures could be correlated with the capping index. It was also found that the addition of polymeric powders was effective to prevent capping.

Affiliations: 1: Technology Development Laboratories, Takeda Chemical Industries Ltd., 2-17-85, Juso-honmachi, Yodogawa, Osaka 532, Japan; 2: Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu 502, Japan


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