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Preparation of trimethylsilylated silica and its interaction with water

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Trimethylsilylation of silica was carried out by means of suspending silica powder in benzene solution of trimethylchlorosilane (TMCS). The degree of trimethylsilylation and the physico-chemical properties of the trimethylsilylated silica (TMS silica) were investigated. The degree of trimethylsilylation was affected by the amount of TMCS to unit weight of silica. However, the concentration of TMCS and the reaction temperature showed no effect. The maximum number of the trimethylsilyl groups (TMS groups) on the TMS silica surface was found to be 2.48/nm2. One water molecule was bound with 1.85 silanol groups on the average. The amount of water absorbed and the heat of immersion decreased with increasing the degree of trimethylsilylation. The TMS silica became stable in water, as the degree of trimethylsilylation proceeded.

Affiliations: 1: Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co. Ltd., Ebie 1-5, Fukushima, Osaka 553, Japan; 2: Pharmaceutical Development, Teikoku Chemical Industry Co. Ltd., Senzo 5-41, Itami, Osaka, Japan; 3: Faculty of Pharmacy, Meijo University, Yagoto-urayama 15, Tempaku, Nagoya, Japan


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