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Computer simulation of fluidized bed granulation

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The effect of sprayed binder droplets on fluidized bed granulation was investigated. It was observed that powders were granulated with a considerably small number of binder droplets and that the granulation rate strongly depended on the size of the binder droplets. These phenomena were simulated by a computer so as to cause the imaginary particle unit to coalesce. It was assumed that the coalescence probability of particles was inversely proportional to the square of the particle size and that some unit particles aggregated with a single binder droplet to form a nucleus in the initial stage of the granulation. The results of the simulation were found to coincide with the experimental data, and the size of the nucleus was proportional to the volume of binder droplets. These results indicated that the granulation rate using various sizes of binder droplets could be predicted using a computer.

Affiliations: 1: Technology Development Laboratories, Takeda Chemical Industries Ltd, 2-17-85, Juso-honmachi, Yodogawa, Osaka 532, Japan; 2: Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu 502, Japan


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