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Spliceosome-mediated RNA trans-splicing in gene therapy and genomics

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In human cells, the majority of the primary transcripts synthesized by RNA polymerase II contain interruptions in the coding sequences, which are known as introns. The spliceosome, a macromolecular enzyme, precisely and efficiently removes these introns in a process known as pre-messenger RNA splicing. This enzyme is also capable of recombining two RNAs in trans in a process known as spliceosome-mediated RNA trans-splicing. In this review, we highlight technologies that take advantage of this RNA trans-splicing, from gene therapy to genomics.

Affiliations: 1: Intronn LLC, 710 West Main Street, Durham, NC 27701, USA and Departments of Genetics, Microbiology and Medicine, Duke University Medical Center, Durham, NC 27710, USA; 2: Intronn LLC, 710 West Main Street, Durham, NC 27701, USA

10.1163/156855800744584
/content/journals/10.1163/156855800744584
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/content/journals/10.1163/156855800744584
2017-08-23

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