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Adult bone marrow-derived angioblasts for improvement of cardiomyocyte function after myocardial ischemia

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image of Gene Therapy and Regulation

Endothelial precursors with phenotypic and functional characteristics of embryonic hemangioblasts are present in human adult bone marrow, and can be used to induce infarct bed vasculogenesis and angiogenesis after experimental myocardial infarction. The neovascularization results in decreased apoptosis of hypertrophied myocytes in the peri-infarct region, long-term salvage and survival of viable myocardium, reduction in collagen deposition, and sustained improvement in cardiac function. It is likely that co-administration of angioblasts will also be needed to supply oxygen and nutrients to exogenously administered cardiomyocyte/mesenchymal stem cells in protocols to regenerate chronically damaged myocardium. Future studies will need to address the timing, relative concentrations, source and route of delivery of each of these cellular populations in animal models of acute and chronic myocardial ischemia.


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