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Urinary trypsin inhibitor levels in the urine of patients with haematological malignancies

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The urinary trypsin inhibitor (UTI) levels in the urine of patients with various haematological malignancies were determined, using automated latex agglutination immunoturbidimetry. The mean UTI levels in urine in acute non-lymphocytic leukaemia, myelodysplastic syndrome, nonHodgkin's lymphoma, and multiple myeloma groups were significantly elevated, compared with the normal control group. It was found that the UTI level in urine changed from an elevated value to a normal value with haematological improvement by chemotherapy in a patient with myelodysplastic syndrome included in a previous study. These results suggest that UTI may be excreted from malignant cells of patients with certain haematological malignancies and that it may be useful as an indicator of chemotherapeutic effects against haematological malignancies.


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