Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Effect of Polypodium leucotomos on acute, chronic and reactivated trinitrobenzene sulphonic acid colitis in rats

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Inflammopharmacology

The effects were examined of a Polypodium leucotomos extract on trinitrobenzene sulphonic acid (TNBS) induced rat colitis. Pretreatment with the extract had a dose-dependent acute anti-inflammatory effect which was maximal at 100 mg/kg/day. This was characterized by preservation of glutathione levels at low doses (25-50 mg/kg) and inhibition of leukotriene B4 synthesis at high doses (50-100 mg/kg). Treatment was also active in chronic colitis, induced by TNBS, as was evident by enhanced colonic fluid absorption and reducing myeloperoxidase levels, while glutathione levels and leukotriene B4 synthesis were unaffected by treatment. Finally, treated animals were partially protected against colitis reactivation, showing lower myeloperoxidase and leukotriene B4 synthesis than controls and normal fluid absorption, but no change in glutathione. In conclusion, Polypodium leucotomos is useful to control experimental colitis (acute, chronic and reactivated) but no common mechanism of action could be delineated, since neither an antioxidative mechanism nor inhibition of leukotriene B4 synthesis can account for the overall effect.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Inflammopharmacology — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation