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Mast cells and peptide induced histamine release

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image of Inflammopharmacology

Mast cells are a heterogeneous population of cells, widely distributed in vertebrates, especially within connective tissues and in areas interfacing the external environment. Mast cells do not circulate as mature cells, it is postulated that mast cell differentiation is not complete until it reaches its target tissue where mast cell phenotype and activity may be modulated by a variety of endogenous and exogenous factors. Mast cell activation may occur via two possible routesimmunological and non-immunological activation. In vitro many physiological compounds, including peptides have been observed to trigger selective mast cell secretion. The mechanism by which peptides induce secretion of inflammatory mediators is unclear. This review concentrates on the main events and signalling pathways of peptide induced mast cell degranulation. Peptidergic activation highlights the multifaceted nature of the mast cell and suggests a pivotal role for the cell in homeostasis.


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