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The anti-inflammatory action of danazol and leuprorelin acetate depot on endometriosis is CRH independent

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Corticotropin-releasing hormone (CRH) is a hypothalamic neuropeptide involved in the neuroendocrine response to stress, also playing a role in cell mediated immune functions. The aim of this study was to determine the circulating in the serum CRH levels in women with endometriosis and investigate the effect of the routinely 6-month administered treatment of danazol or leuprorelin acetate depot on these hormonal levels. Serum CRH levels were not significantly different in women with endometriosis and in the control group. The 6-month danazol or leuprorelin treatment had no effect on the levels of CRH. Three months after danazol treatment CRH levels were significantly lower (p < 0.005) than those before treatment. In contrast, after treatment with leuprorelin, CRH levels were significantly higher (p < 0.001). Our results suggest that endometriosis is not associated with CRH and that danazol as well as leuprorelin acetate depot have no effect on these levels during the treatment-specific period. However, they both showed significant fluctuations after the administration of these compounds ceased.

Affiliations: 1: Department of Obstetrics and Gynecology, University of Crete, Greece; 2: Department of Biology, University of Crete, Greece; 3: Department of Obstetrics and Gynecology, University of Crete, Greece, Department of Biology, University of Crete, Greece


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