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Role of small GTP-binding proteins and cytoskeleton in gastric acid secretion

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image of Inflammopharmacology

When parietal cells are stimulated, the tubulovesicles containing H,K-ATPase, the essential proton pump, fuse with the apical membrane forming microvilli. In this procedure, small GTP binding proteins, Rab11, ARF, and Rho play important roles. Rab11 and ARF are considered to regulate the intracellular vesicular transport and fusion events, whereas Rho appears to conduct an inhibitory signal via the regulation of the actin cytoskeleton. The nature of F-actin is different between basolateral and apical membrane sites. The former plays a role to connect Ca2+ stores to plasma membrane making effective coupling between muscarinic receptor and IP3 receptor. The microfilaments supporting apical membrane appear to be negatively regulated by Rho/Rho-kinase in contrast to other secretory cells. For the elucidation of intracellular membrane traffic, which is the main issue of cell biology today, the parietal cell is a good model for studying this mechanism.


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