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Acetic acid ulcers: a new method for producing solitary chronic ulcers in rat stomachs by intraluminal application of acetic acid solution

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image of Inflammopharmacology

Acetic acid ulcer models remain popular because of the simplicity of the procedures, the reliability of development, and a strong resemblance to human ulcers in terms of both pathology and healing processes. Such ulcer models, however, possess the drawback of invariable adherence of the ulcer base to the liver. The present study demonstrates the production of new acetic acid ulcer, i.e., a single ulcer per stomach with bases that do not adhere to the liver. This new model will prove useful for both screening antiulcer medications and elucidating the mechanisms underlying ulcer healing.


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