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Biochemical aspects and functional role of the copper-containing amine oxidases

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image of Inflammopharmacology

The copper-containing amine oxidases of the class EC share many biochemical similarities. They contain cupric copper and catalyse the same general reaction. In mammals, diamine oxidase has a role in the metabolism of histamine, some other diamines and spermine oxidase, involved in the metabolism of polyamines. However, the functional role of benzylamine oxidase (BAO) and the tissue semicarbazide-sensitive amine oxidases (SSAO) is still under investigation. Circulating BAO is derived from the tissue SSAO. It has a high affinity for benzylamine and its role in the extra-cellular matrix includes the maturation of pro-elastin and control of the inflammatory process.

Affiliations: 1: Department of Pharmacology, University of Florence, Florence, Italy


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