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Biochemical aspects and functional role of the copper-containing amine oxidases

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image of Inflammopharmacology

The copper-containing amine oxidases of the class EC 1.4.3.6 share many biochemical similarities. They contain cupric copper and catalyse the same general reaction. In mammals, diamine oxidase has a role in the metabolism of histamine, some other diamines and spermine oxidase, involved in the metabolism of polyamines. However, the functional role of benzylamine oxidase (BAO) and the tissue semicarbazide-sensitive amine oxidases (SSAO) is still under investigation. Circulating BAO is derived from the tissue SSAO. It has a high affinity for benzylamine and its role in the extra-cellular matrix includes the maturation of pro-elastin and control of the inflammatory process.

Affiliations: 1: Department of Pharmacology, University of Florence, Florence, Italy

10.1163/156856003322315550
/content/journals/10.1163/156856003322315550
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/content/journals/10.1163/156856003322315550
2003-09-01
2016-12-06

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