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Prostaglandin F2α produced by inducible cyclooxygenase may contribute to the resolution of inflammation

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image of Inflammopharmacology

Cyclooxygenase-2 may play a role in resolution of carrageenan-induced pleurisy in rats by generating anti-inflammatory prostanoids. Here, we show exudate prostaglandin F concentrations rise during resolution of this model. These were reduced by the selective cyclooxygenase-2 inhibitor NS-398, which exacerbated inflammation. Concomitant treatment with NS-398 and the synthetic FP receptor agonist fluprostenol reversed this exacerbation. This suggests prostaglandin F produced by cyclooxygenase-2 contributes to resolution of this inflammatory reaction.

Affiliations: 1: Department of Experimental Pathology, William Harvey Research Institute, St Bartholomew's & Royal London School of Medicine & Dentistry, Charterhouse Square, London EC1M 6BQ, UK


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