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Lansoprazole binding to the neutrophils in dextran sulfate sodium-induced rat colitis

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image of Inflammopharmacology

To clarify the effector sites of lansoprazole in the colonic mucosa during the formation of colitis, dextran sulfate sodium-induced colitis was induced by the oral administration of 3% aqueous solution for 3 and 7 days. The effector sites of [3H]lansoprazole were examined by the intra-aortic infusion of the radiolabelled compound and the autoradiographic tracing of water-soluble compounds. As a result, the [3H]lansoprazole binding in the control rat colon was negligible, while in dextran sulfate sodium-treated rats specific binding sites of [3H]lansoprazole were recognized in the cytoplasm of the mesenchymal cells, and most of them coincided with polymorphonuclear leucocytes and macrophages.

Affiliations: 1: Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan; 2: Kitasato Institute for Life Sciences & Graduate School of Infection Control Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan; 3: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan; 4: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan


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