Cookies Policy
X

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Taste effects of antiretroviral drugs on chorda tympani responses in gerbil

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Sensory Neuron
For more content, see Primary Sensory Neuron.

In clinical reports, HIV-infected patients complain that antiretroviral drugs produce unpleasant tastes that affect compliance with their medication regimen. In this study, taste effects of seven antiretroviral drugs (protease inhibitors and nucleoside analogs) were investigated in a gerbil model. Electrophysiological recordings were obtained from the chorda tympani nerve after lingual application of HIV medications. The effect of adaptation of the tongue to HIV medications on other taste stimuli with salty, sweet, sour and bitter qualities was also determined to simulate the presence of drug in the saliva. Four drugs (ritonavir, lamivudine, indinavir and didanosine) produced taste responses in the chorda tympani nerve of the gerbil at 0.625 mM and higher. Zidovudine, saquinavir and stavudine gave no taste responses at concentrations below 10 mM. The protease inhibitors saquinavir (2 mM) and ritonavir (10 mM) suppressed most taste stimuli with the greatest effect on bitter and sweet qualities. The nucleoside analog lamivudine gave a taste response at 20 mM and produced the greatest suppression on sour tastes. Results show that protease inhibitors had a more potent effect on chorda tympani responses in gerbil than nucleoside analogs.

Affiliations: 1: Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA; 2: Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA

10.1163/156856500744766
/content/journals/10.1163/156856500744766
dcterms_title,pub_keyword,dcterms_description,pub_author
6
3
Loading
Loading

Full text loading...

/content/journals/10.1163/156856500744766
Loading

Data & Media loading...

http://brill.metastore.ingenta.com/content/journals/10.1163/156856500744766
Loading

Article metrics loading...

/content/journals/10.1163/156856500744766
2000-09-28
2016-12-07

Sign-in

Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
     
    Sensory Neuron — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation