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Optimization of glycine crystallization by the golden section search

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image of Process Control and Quality

The yield and the purity of glycine obtained after ammonolysis of monochloracetic acid with hexamethylenetetramine followed by a crystallization in a hydromethanolic medium depend on the fraction of methanol in the mixture. Influence of the solvent composition on the solubility of a restored reaction mixture as a function of temperature was first studied for diverse methanol weight fractions in the medium. The results showed that the best conditions for crystallization should be located in a 70-100% methanol weight fraction range with a temperature lower than 10°C. These conditions were then optimized by the golden section search. The results obtained confirmed previous trials and indicated that the optimal methanol weight fraction is 80%. In these conditions, the yield of pure glycine obtained by crystallization was about 92.3% (for a final temperature of 7°C) and the crystals were 98% pure.


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