Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Epc-K1 Protects Neuronal Cells From Peroxynitrite-Mediated Oxidative Damage

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

This Article is currently unavailable for purchase.
Add to Favorites
You must be logged in to use this functionality

Cover image Placeholder

Protective effects of EPC-K1 (L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyldecyl)-2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt, a difunctional derivative of vitamin C and vitamin E) on neuronal cell damage mediated by peroxynitrite were studied. Primary cultures of cerebellar granule cells were exposed to peroxynitrite by treatment with 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1), which generated nitric oxide and superoxide anion simultaneously upon decomposition. The results showed that SIN-1 treatment triggered time-dependent cell death, which was accompanied by the decrease in the cellular GSH level, the increase in the lipid peroxidation level, and the alteration of cell membrane biophysical characteristics. EPC-K1 showed only moderate scavenging effect on peroxynitrite, but could effectively protect neuronal cells from oxidative damage mediated by peroxynitrite.

Affiliations: 1: Department of Molecular and Cellular Biophysics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 2: Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Okayama 700, Japan


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation