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Epc-K1 Protects Neuronal Cells From Peroxynitrite-Mediated Oxidative Damage

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Protective effects of EPC-K1 (L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyldecyl)-2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt, a difunctional derivative of vitamin C and vitamin E) on neuronal cell damage mediated by peroxynitrite were studied. Primary cultures of cerebellar granule cells were exposed to peroxynitrite by treatment with 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1), which generated nitric oxide and superoxide anion simultaneously upon decomposition. The results showed that SIN-1 treatment triggered time-dependent cell death, which was accompanied by the decrease in the cellular GSH level, the increase in the lipid peroxidation level, and the alteration of cell membrane biophysical characteristics. EPC-K1 showed only moderate scavenging effect on peroxynitrite, but could effectively protect neuronal cells from oxidative damage mediated by peroxynitrite.

Affiliations: 1: Department of Molecular and Cellular Biophysics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 2: Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Okayama 700, Japan

10.1163/156856700X00598
/content/journals/10.1163/156856700x00598
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/content/journals/10.1163/156856700x00598
2000-01-01
2017-04-29

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