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Kinetic Scavenging Effect of Chinonin On No and Oxygen Free Radicals Generated From Ischemia Reperfusion Myocardium and Its Protective Effect On the Myocardium

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The kinetic scavenging effect of chinonin on NO and oxygen free radicals generated from ischemia reperfusion myocardium and its protective effect on the myocardium were studied by electron spin resonance (ESR) spin trapping technique. It was found that after 20 minutes ischemia, the first peak of oxygen free radical appeared at about 0.5 minutes after the beginning of reperfusion, then the release of oxygen free radicals decreased with time. The second peak appeared at about 3 minutes. Similarly, there were two peaks of creatine kinase (CK) release, which indicated the myocardial damage, the first one appeared concomitantly with the first oxygen free radical peak but the second one appeared later about 1 minute after appearance of the second peak of oxygen free radicals. The release of NO free radicals was not significant in the absence of L-arginine. However, it increased significantly in the presence of L-arginine and it also possesses a biphase profile. It could protect the ischemia-reperfusion damage in the presence of low concentration of L-arginine (0.1 mM), but in high L-arginine concentration (10 mM) it generated higher concentrations of NO leading to a more serious ischemia-reperfusion damage. Addition of chinonin could scavenge the free radicals and protect the ischemia-reperfusion injury, especially in the second phase. The reduction stoichiometry of chinonin for Fe(III) was measured.

Affiliations: 1: Institute of Biophysics, Academia Sinica, Beijing CHINA 100101; 2: College of Life Science, Beijing University, Beijing CHINA 100080; 3: Medical and Pharmaceutical Research Institute, 999 Enterprise Group, Shenzhen CHINA 518026


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