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Free Radical Scavenging Ability of Some 5-Aminosalicylic Acid Derivatives

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Theories explaining the clinically proven efficacies of 5-aminosalicylic acid and its derivatives sulfasalazine and olsalazine in the treatment of inflammatory bowel disease have invoked the neutralization or scavenging of reactive free radicals. This is a preliminary study comparing the relative scavenging abilities of these 5-ASA derivatives towards the stable free radicals 2,2-diphenyl-1 picrylhydrazyl (DPPH) and galvinoxyl with several compounds including phenols, acetaminophen and vitamins C, K and E which have well documented antioxidant and radical scavenging capabilities both in solution and in biological systems.

Affiliations: 1: Faculty of Medicine Queen's University, Kingston, Canada K7L 3N6; 2: Department of Chemistry Queen's University Kingston, Canada K7L 3N6


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