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Chemical Nucleases Crafted From Core Oxalo Retro-Bispeptides#

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Copper complexes of C2 symmetric core oxalo retro-bispeptides (HO-Aaa-COCO-Aaa-OH, Aaa = Aib, L-Leu, L-Tyr and L-Trp) have been synthesized and demonstrated to bind and cleave double stranded DNA at pH 7 under physiological conditions.

Affiliations: 1: Discovery Laboratory, Indian Institute of Chemical Technology, Hyderabad-500 007, INDIA


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