Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Zeolites as Model Solids for Investigations On the Role of Iron At the Solid-Liquid Interface in Particulate Toxicity

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

This Article is currently unavailable for purchase.
Add to Favorites
You must be logged in to use this functionality

Cover image Placeholder

In order to investigate the molecular mechanism whereby iron in asbestos and in other iron containing fibres plays a crucial role in fibre induced carcinogenicity, two Fe2+-exchanged zeolites (Y and H-ZSM-5) have been prepared and used as model solids. Fe-Y was active both in free radical generation via hydrogen abstraction and in single strand DNA damage, but lost both these properties when oxidized by hydrogen peroxide. Fe-ZSM-5, on the other hand, was nearly inactive. Iron chelators and reductants (ascorbate, citrate and EDTA) enhance the activity in DNA single strand breaks. Moreover, they reactivate oxidized Fe-Y and activate Fe-ZSM-5. Iron is mobilized and Fe3+ is partially reduced to Fe2+. The most pronounced effect was found when citrate was present together with ascorbate. H-abstraction turns out to be a rather general reaction, occurring also with peptides as target molecules. In this case EPR spectra show that more than one type of radical moiety is generated.

Affiliations: 1: Dipartimento di Chimica Inorganica, Chimica Fisica e Chimica dei Materiali, Università di Torino, via P.Giuria 7, 10125 Torino, Italy; 2: Department of Chemistry and Biochemistry, Utah State University. Logan, UT 84322-0300, USA


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation