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Effect of repeated treatment with lamotrigine on locomotor activity and on DOI-elicited wet dog shakes in rats

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Lamotrigine is a new anticonvulsant, and it is also effective for bipolar disorder, especially for bipolar depression. In this study, we have investigated the effect of single or repeated treatment with lamotrigine on some behavioral response in rats to understand its action mechanisms on mood disorder.

As for acute effect of lamotrigine, single treatment with lamotrigine (5, 10 and 20 mg/kg) did not change the intensity of 8-OH-DPAT-induced flat body posture, the frequency of DOI-elicited wet dog shakes (WDSs), or spontaneous locomotor activity in rats.

As for chronic effect of lamotrigine, rats were subcutaneously injected with dexamethasone (1 mg/kg) and/or lamotrigine (10 mg/kg) intraperitoneally for 14 days. One day after the last administration, spontaneous locomotor activity of the rats was measured, and subsequently DOIinduced WDSs were observed. Repeated treatment with lamotrigine (10 mg/kg) itself facilitated spontaneous locomotor activity. Repeated dexamethasone injection significantly enhanced DOIproduced WDSs, and the enhancement declined with repeated treatment with lamotrigine (10 mg/kg). These findings are similar to the effect of some antidepressants and mood stabilizers on these behaviors, and can explain some action mechanisms of lamotrigine on mood disorder.


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