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Serotonin-mediated neurotransmission in the pyramidal cells of the rat hippocampus

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Serotonin (5-HT)-mediated neurotransmission in the pyramidal cell layer of the rat hippocampus was reviewed, with special reference to our findings on a selective 5-HT reuptake inhibitor (SSRI) fluvoxamine. In the hippocampus, fluvoxamine increased the extracellular levels of 5-HT and increased the evoked population spike (PS) amplitudes in the CA1 and CA3 pyramidal cells. Fluvoxamine-induced synaptic facilitation was augmented by the 5-HT1A receptor antagonist NAN 190, while it was prevented by the 5-HT4 receptor antagonist GR 113808 and the 5-HT7 receptor antagonist DR4004 in the CA1. They were abolished by either NAN 190 or DR 4004 in the CA3. A 5-HT1A receptor agonist, tandospilone, mimicked the fluvoxamine-induced synaptic effects in the pyramidal cells in a NAN 190-sensitive manner. These results suggest that endogenous 5-HT-mediated neurotransmission is regulated by 5-HT1A and 5-HT4 /5-HT7 receptors in an opposite manner in the CA1 field. On the contrary, both 5-HT1A and 5-HT7 receptors appear to be positively coupled with 5-HT-mediated synaptic responses in the CA3 field. These regional differences in 5-HT receptor-mediated neurotransmission in the pyramidal cells, may play a significant role in the hippocampal functions, such as fear/anxiety expression and emotional memory processing, and may be partly responsible for anxiolytic effects of SSRIs.


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