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Urinary 5-hydroxyindoleacetic acid excretion and kaolin ingestion after a single administration of cisplatin in the delayed emesis rat model

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In this study, rat kaolin ingestion (pica) and serial urinary 5-hydroxyindoleacetic acid (5-HIAA) excretions were determined for three days after a single administration of low-dose cisplatin (5 mg/kg, intraperitoneal, i.p.). We found that cisplatin induced acute (first 24 hours after chemotherapy) and delayed phases (24-72 hours after chemotherapy) of kaolin ingestion in rats. An increase in urinary 5-HIAA excretion was also observed in the cisplatin-administered group. These results suggest that 5-HT is involved in delayed emesis, and that urinary 5-HIAA excretion can be used as a marker in the study of delayed emesis.


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