Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Urinary 5-hydroxyindoleacetic acid excretion and kaolin ingestion after a single administration of cisplatin in the delayed emesis rat model

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Biogenic Amines

In this study, rat kaolin ingestion (pica) and serial urinary 5-hydroxyindoleacetic acid (5-HIAA) excretions were determined for three days after a single administration of low-dose cisplatin (5 mg/kg, intraperitoneal, i.p.). We found that cisplatin induced acute (first 24 hours after chemotherapy) and delayed phases (24-72 hours after chemotherapy) of kaolin ingestion in rats. An increase in urinary 5-HIAA excretion was also observed in the cisplatin-administered group. These results suggest that 5-HT is involved in delayed emesis, and that urinary 5-HIAA excretion can be used as a marker in the study of delayed emesis.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Biogenic Amines — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation