Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deficit/hyperactivity disorder

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

Attention-deficit/hyperactivity disorder (AD/HD) is defined as a developmental disorder, manifested by inattention and/or hyperactivity-impulsivity. Neuropsychological studies suggest impaired cognitive function including working memory. 3-5% of school-aged children show signs of this disorder with male predominance. This article provides an overview of the symptomatic relevance of juvenile stroke-prone spontaneously hypertensive rats (SHRSP) as an animal model of AD/HD. To characterize behavioral alterations, i.e. hyperactivity-impulsivity and/or inattention, SHRSP were diagnosed according to motor activity, as well as emotional and cognitive behaviors with or without methylphenidate, a first choice drug for AD/HD therapy. Ambulatory and rearing activities in the open-field environment were significantly higher in SHRSP than in Wistar-Kyoto rats. In the elevated plus-maze task, anxiety-related behavior as an index of impulsivity was significantly increased in SHRSP. In the Y-maze task, spontaneous alternation behavior as an index of attention was significantly lowered in male, but not in female SHRSP, indicating gender specificity. Methylphenidate significantly attenuated locomotor hyperactivity at low doses, and dose-dependently improved the spontaneous alternation deficit in SHRSP.On the basis of these behavioral and pharmacological features, we have presented here that juvenile SHRSP are an appropriate animal model of AD/HD, for providing insights into the pathogenesis and developing therapeutic strategies.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Biogenic Amines — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation