Cookies Policy
X

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Intrathecal spermine and spermidine at high-doses induce antinociceptive effects in the mouse capsaicin test

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

This Article is currently unavailable for purchase.
Add to Favorites
You must be logged in to use this functionality

The antinociceptive effects of intrathecally (i.t.) administered high doses of spermine and spermidine, endogenous polyamines, were examined in the mouse capsaicin test. Spermine (2.5-10 nmol) and spermidine (10 and 15 nmol), when administered i.t. 5 min before the injection of capsaicin solution (1600 ng) into the plantar surface of a hindpaw, produced a significant reduction of the nociceptive behavioral response. Ifenprodil (2 and 4 nmol), an antagonist of the polyamine recognition site on N-methyl-D-aspartate (NMDA) receptor ion-channel complex, co-administered with spermine or spermidine significantly inhibited antinociception induced by both polyamines. These results indicate that spermine- and spermidine-induced antinociception may be mediated via the polyamine recognition site on NMDA receptor ion-channel complex in the mouse spinal cord.

10.1163/15693910260698276
/content/journals/10.1163/15693910260698276
dcterms_title,pub_keyword,dcterms_description,pub_author
10
5
Loading
Loading

Full text loading...

/content/journals/10.1163/15693910260698276
Loading

Data & Media loading...

http://brill.metastore.ingenta.com/content/journals/10.1163/15693910260698276
Loading

Article metrics loading...

/content/journals/10.1163/15693910260698276
2017-12-11

Sign-in

Can't access your account?
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation