Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

An experimental rat model of Parkinson's disease induced by Japanese encephalitis virus

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

Access this article

+ Tax (if applicable)
Add to Favorites
You must be logged in to use this functionality

image of Biogenic Amines

In adult Fischer rats sacrificed 12 weeks after infection with Japanese encephalitis virus (JEV) at the age of 13 days, neuronal loss with gliosis was confined mainly to the zona compacta of the bilateral substantia nigra, without lesions in the cerebral cortex and cerebellum. Furthermore, the most severe lesions were in the central part of zona compacta; the lateral cell groups were less affected. In addition, immunohistochemical study with anti-tyrosine hydroxylase (TH) showed that the number of TH-positive neurons was decreased significantly in the substantia nigra compared with that in controls, while comparable TH-positive neurons were found in the basal ganglia in the JEV-treated rats and age-matched controls. Thus, the distribution of the pathologic lesions in infected rats resembled those found in Parkinson's disease. The immunohistochemical studies failed to detect JEV antigens in any region of the rat brain and the JEV genome was undetectable in the substantia nigra and the cerebral cortex by reverse transcription-polymerase chain reaction. JEV-infected rats showed marked bradykinesia. Significant behavioral improvement was observed upon administration of L-DOPA. The findings suggest that JEV infection of rats under the conditions described may serve as a model of virus induced Parkinson's disease. We could evaluate the possibilities of some new drugs using this rat model.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Tools

  • Add to Favorites
  • Printable version
  • Email this page
  • Subscribe to ToC alert
  • Get permissions
  • Recommend to your library

    You must fill out fields marked with: *

    Librarian details
    Your details
    Why are you recommending this title?
    Select reason:
    Biogenic Amines — Recommend this title to your library
  • Export citations
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation