Cookies Policy

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

I accept this policy

Find out more here

Potential roles of interstitial fluid adenosine in the regulation of renal hemodynamics

No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.
The full text of this article is not currently available.

Brill’s MyBook program is exclusively available on BrillOnline Books and Journals. Students and scholars affiliated with an institution that has purchased a Brill E-Book on the BrillOnline platform automatically have access to the MyBook option for the title(s) acquired by the Library. Brill MyBook is a print-on-demand paperback copy which is sold at a favorably uniform low price.

This Article is currently unavailable for purchase.
Add to Favorites
You must be logged in to use this functionality

Adenosine exerts membrane receptor-mediated effects on renal hemodynamics and function. Endogenously produced adenosine is proposed to be formed primarily by renal tubular epithelial cells and approaches the vascular smooth cells of the renal vasculature from the extracellular space, i.e. the interstitium. Hence, it is important to determine the dynamics of adenosine levels in renal interstitial fluid. Indeed, many studies have indicated that the effects of adenosine on renal hemodynamics depend on its concentration in the interstitium. Furthermore, in vitro studies reveal that adenosine in the renal interstitial fluid binds to membrane receptors from the adventitial side and initiates renal microvascular responses. Recently, we developed a renal microdialysis method to monitor the concentration of adenosine in renal interstitial fluid. This method is well suited for in vivo studies investigating alterations in renal interstitial adenosine levels. In this review, we summarize the literature pertaining to alterations in renal interstitial fluid concentrations of adenosine in some pathophysiological conditions. Potential roles of interstitial adenosine for regulating renal hemodynamics were also discussed.


Full text loading...


Data & Media loading...

Article metrics loading...



Can't access your account?
  • Key

  • Full access
  • Open Access
  • Partial/No accessInformation